- The house where Sheldon and Leonard live has only one staircase and one landing. Every time the characters were taking the stairs to their floor, the shooting crew just changed the look of the doors.
- Raj’s apartment and Howard and Bernadette’s house never appear in the same episode because both the apartment and the house are the same set.
- The names of all the episodes of the sitcom are the names of real scientific principles, theories, and experiments, except for the pilot which was just called, Pilot.
- Initially, this TV series was supposed to be called Penny, Lenny, and Kenny.
- At the end of each episode, scriptwriter Chuck Lorre shows so-called vanity cards in which he makes jokes, shares his thoughts and even speaks to the audience directly.
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